As serial link speeds increase, systems become more “Stressed”. Loss, low probability deterministic jitter, crosstalk aggression from densely packed signal nets, via and connector impedance and associated resonances, and package and power delivery issues all add their own jitter density function, resulting in a net jitter picture that is inherently complicated. This paper represents a rigorous and practical crosstalk analysis of 10Gbps and higher serial data transmission systems, which will begin at pre-layout 3D EM extraction, continue with the material parameters identification and post-layout analysis and end with direct jitter measurement and separation. We believe this is one of the timeliest of topics in signal integrity at the present time.